7X1N

Crystal structure of MEF2D-MRE complex

Summary for 7X1N

• Entry DOI: 10.2210/pdb7x1n/pdb
• Descriptor: DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*G)-3'), DNA (5'-D(P*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3'), Myocyte enhancer factor 2D/deleted in azoospermia associated protein 1 fusion protein, ... (4 entities in total)
• Functional Keywords: acute lymphoblastic leukemia, mef2d-fusions, mef2d-hnrnpul1, mef2d-dna interaction, leukemogenesis, prognostic markers, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 63892.72

Authors

Zhang, H.,Zhang, M.,Wang, Q.Q.,Chen, Z.,Chen, S.J.,Meng, G. (deposition date: 2022-02-24, release date: 2022-05-25, Last modification date: 2023-11-29)

• Primary citation: Zhang, M.,Zhang, H.,Li, Z.,Bai, L.,Wang, Q.,Li, J.,Jiang, M.,Xue, Q.,Cheng, N.,Zhang, W.,Mao, D.,Chen, Z.,Huang, J.,Meng, G.,Chen, Z.,Chen, S.J.; Functional, structural, and molecular characterizations of the leukemogenic driver MEF2D-HNRNPUL1 fusion.; Blood, 140:1390-1407, 2022; PubMed: 35544603; DOI: 10.1182/blood.2022016241

Experimental method

X-RAY DIFFRACTION (3.315 Å)