7WYX

Cryo-EM structure of Na+,K+-ATPase in the E2P state formed by ATP with istaroxime

Summary for 7WYX

• Entry DOI: 10.2210/pdb7wyx/pdb
• Related: 7WYU 7WYV 7WYW 7WYY 7WYZ 7WZ0
• EMDB information: 32897
• Descriptor: Sodium/potassium-transporting ATPase subunit alpha, ADENOSINE-5'-TRIPHOSPHATE, (3E,5S,8R,9S,10R,13S,14S)-3-(2-azanylethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione, ... (14 entities in total)
• Functional Keywords: na+, k+-atpase, membrane protein, ion transport, transport protein
• Biological source: Squalus acanthias (spiny dogfish); More
• Total number of polymer chains: 6
• Total formula weight: 348318.14

Authors

Kanai, R.,Cornelius, F.,Vilsen, B.,Toyoshima, C. (deposition date: 2022-02-16, release date: 2022-04-27)

• Primary citation: Kanai, R.,Cornelius, F.,Vilsen, B.,Toyoshima, C.; Cryoelectron microscopy of Na + ,K + -ATPase in the two E2P states with and without cardiotonic steroids.; Proc.Natl.Acad.Sci.USA, 119:e2123226119-e2123226119, 2022; PubMed: 35380894; DOI: 10.1073/pnas.2123226119

Experimental method

ELECTRON MICROSCOPY (3.4 Å)