7WMN

A novel chemical derivative(89) of THRB agonist

Summary for 7WMN

Entry DOI	10.2210/pdb7wmn/pdb
Descriptor	Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2, 2-[[7-[2,6-dimethyl-4-(3-methylphenyl)carbonyl-phenoxy]-1-methoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid, ... (4 entities in total)
Functional Keywords	transcription factor, ligand, transcription
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	31275.10
Authors	Yao, B.Q.,Li, Y. (deposition date: 2022-01-15, release date: 2022-05-18, Last modification date: 2023-11-29)
Primary citation	Li, Q.,Yao, B.,Zhao, S.,Lu, Z.,Zhang, Y.,Xiang, Q.,Wu, X.,Yu, H.,Zhang, C.,Li, J.,Zhuang, X.,Wu, D.,Li, Y.,Xu, Y. Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist. J.Med.Chem., 65:7193-7211, 2022 Cited by PubMed: 35507418 DOI: 10.1021/acs.jmedchem.2c00144 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.57 Å)

Structure validation