7WM4

Cryo-EM structure of tetrameric TLR3 in complex with dsRNA (90 bp)

Summary for 7WM4

Entry DOI	10.2210/pdb7wm4/pdb
EMDB information	32599
Descriptor	Toll-like receptor 3, RNA (81-MER), beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	innate immunity, immune system, immune system-rna complex, immune system/rna
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	6
Total formula weight	377646.32
Authors	Sakaniwa, K.,Ohto, U.,Shimizu, T. (deposition date: 2022-01-14, release date: 2023-01-25, Last modification date: 2023-08-30)
Primary citation	Sakaniwa, K.,Fujimura, A.,Shibata, T.,Shigematsu, H.,Ekimoto, T.,Yamamoto, M.,Ikeguchi, M.,Miyake, K.,Ohto, U.,Shimizu, T. TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction. Nat Commun, 14:164-164, 2023 Cited by PubMed: 36631495 DOI: 10.1038/s41467-023-35844-2 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation