7WEL

Human Nav1.8 with A-803467, class II

Summary for 7WEL

Entry DOI	10.2210/pdb7wel/pdb
EMDB information	32451
Descriptor	Sodium channel protein type 10 subunit alpha, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	voltage-gated sodium channel, nav, activation, selectivity, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	237929.48
Authors	Yan, N.,Pan, X.J.,Huang, X.S.,Huang, G.X. (deposition date: 2021-12-23, release date: 2022-08-03, Last modification date: 2022-09-21)
Primary citation	Huang, X.,Jin, X.,Huang, G.,Huang, J.,Wu, T.,Li, Z.,Chen, J.,Kong, F.,Pan, X.,Yan, N. Structural basis for high-voltage activation and subtype-specific inhibition of human Na v 1.8. Proc.Natl.Acad.Sci.USA, 119:e2208211119-e2208211119, 2022 Cited by PubMed: 35858452 DOI: 10.1073/pnas.2208211119 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation