7W7Y

The crystal structure of human abl1 kinase domain in complex with ABL2-A5

Summary for 7W7Y

• Entry DOI: 10.2210/pdb7w7y/pdb
• Descriptor: Tyrosine-protein kinase ABL1, 5-[3-(5-methanoyl-2-methoxy-4-oxidanyl-phenyl)-1~{H}-pyrrolo[2,3-b]pyridin-5-yl]-~{N},~{N}-dimethyl-pyridine-3-carboxamide (3 entities in total)
• Functional Keywords: abl1, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 64955.92

Authors

Zhu, C.,Zhang, Z.M. (deposition date: 2021-12-06, release date: 2022-04-27, Last modification date: 2023-11-29)

• Primary citation: Chen, P.,Sun, J.,Zhu, C.,Tang, G.,Wang, W.,Xu, M.,Xiang, M.,Zhang, C.J.,Zhang, Z.M.,Gao, L.,Yao, S.Q.; Cell-Active, Reversible, and Irreversible Covalent Inhibitors That Selectively Target the Catalytic Lysine of BCR-ABL Kinase.; Angew.Chem.Int.Ed.Engl., 61:e202203878-e202203878, 2022; PubMed: 35438229; DOI: 10.1002/anie.202203878

Experimental method

X-RAY DIFFRACTION (2.20003021871 Å)