7W2Z

Cryo-EM structure of the ghrelin-bound human ghrelin receptor-Go complex

Summary for 7W2Z

• Entry DOI: 10.2210/pdb7w2z/pdb
• EMDB information: 32268
• Descriptor: Guanine nucleotide-binding protein G(o) subunit alpha, Growth hormone secretagogue receptor type 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: gpcr, ghrelin, endogenous agonist, class a gpcr, peptide receptor, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 142349.50

Authors

Qin, J.,Ming, Q.,Ji, S.,Mao, C.,Shen, D.,Zhang, Y. (deposition date: 2021-11-24, release date: 2022-01-19, Last modification date: 2022-02-16)

• Primary citation: Qin, J.,Cai, Y.,Xu, Z.,Ming, Q.,Ji, S.Y.,Wu, C.,Zhang, H.,Mao, C.,Shen, D.D.,Hirata, K.,Ma, Y.,Yan, W.,Zhang, Y.,Shao, Z.; Molecular mechanism of agonism and inverse agonism in ghrelin receptor.; Nat Commun, 13:300-300, 2022; PubMed: 35027551; DOI: 10.1038/s41467-022-27975-9

Experimental method

ELECTRON MICROSCOPY (2.8 Å)