7W2P

Tudor domain of SMN in complex with a small molecule

Summary for 7W2P

• Entry DOI: 10.2210/pdb7w2p/pdb
• Descriptor: Survival motor neuron protein, 2-[(4-fluorophenyl)methyl]-2-azatricyclo[7.3.0.0^{3,7}]dodeca-1(9),3(7)-dien-8-imine, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: smn, tudor, small molecule, rna binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 7683.22

Authors

Li, W.,Arrowsmith, C.H.,Edwards, A.M.,Liu, Y.,Min, J. (deposition date: 2021-11-24, release date: 2022-10-05, Last modification date: 2023-11-29)

• Primary citation: Liu, Y.,Iqbal, A.,Li, W.,Ni, Z.,Wang, Y.,Ramprasad, J.,Abraham, K.J.,Zhang, M.,Zhao, D.Y.,Qin, S.,Loppnau, P.,Jiang, H.,Guo, X.,Brown, P.J.,Zhen, X.,Xu, G.,Mekhail, K.,Ji, X.,Bedford, M.T.,Greenblatt, J.F.,Min, J.; A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II.; Nat Commun, 13:5453-5453, 2022; PubMed: 36114190; DOI: 10.1038/s41467-022-33229-5

Experimental method

X-RAY DIFFRACTION (1.15 Å)