7VYT

Crystal structure of human TIGIT(23-129) in complex with the scFv fragment of anti-TIGIT antibody MG1131

Summary for 7VYT

Entry DOI	10.2210/pdb7vyt/pdb
Descriptor	T-cell immunoreceptor with Ig and ITIM domains, MG1131 heavy chain variable region, MG1131 light chain variable region, ... (5 entities in total)
Functional Keywords	antibody, immune checkpoint, tigit, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	77343.30
Authors	Jeong, B.-S.,Nam, H.,Kim, M.,Oh, B.-H. (deposition date: 2021-11-15, release date: 2022-03-02, Last modification date: 2023-11-29)
Primary citation	Jeong, B.S.,Nam, H.,Lee, J.,Park, H.Y.,Cho, K.J.,Sheen, J.H.,Song, E.,Oh, M.,Lee, S.,Choi, H.,Yang, J.E.,Kim, M.,Oh, B.H. Structural and functional characterization of a monoclonal antibody blocking TIGIT. Mabs, 14:2013750-2013750, 2022 Cited by PubMed: 35090381 DOI: 10.1080/19420862.2021.2013750 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation