7VUE

Structural insight of the molecular mechanism of cilofexor bound to FXR

Summary for 7VUE

Entry DOI	10.2210/pdb7vue/pdb
Descriptor	Bile acid receptor, Peptide from Nuclear receptor coactivator 2, 2-[3-[4-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-2-chloranyl-phenyl]-3-oxidanyl-azetidin-1-yl]pyridine-4-carboxylic acid, ... (4 entities in total)
Functional Keywords	nuclear receptor, ligand binding, nuclear protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	28742.19
Authors	Jiang, L.,Chen, Y.C. (deposition date: 2021-11-02, release date: 2022-03-16, Last modification date: 2023-11-29)
Primary citation	Jiang, L.,Liu, X.,Wei, H.,Dai, S.,Qu, L.,Chen, X.,Guo, M.,Chen, Y. Structural insight into the molecular mechanism of cilofexor binding to the farnesoid X receptor. Biochem.Biophys.Res.Commun., 595:1-6, 2022 Cited by PubMed: 35091108 DOI: 10.1016/j.bbrc.2022.01.069 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.601 Å)

Structure validation