7V4E

Crystal Structure of VpsR display novel dimeric architecture and c-di-GMP binding: mechanistic implications in oligomerization, ATPase activity and DNA binding.

Summary for 7V4E

Entry DOI	10.2210/pdb7v4e/pdb
Descriptor	VpsR, SULFATE ION, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one) (3 entities in total)
Functional Keywords	x-ray crystallography; biofilm; fluorescence quenching; atpase activity; second-messenger, transcription
Biological source	Vibrio cholerae
Total number of polymer chains	2
Total formula weight	91017.17
Authors	Chakrabortty, T.,Sen, U. (deposition date: 2021-08-12, release date: 2022-04-06, Last modification date: 2023-11-29)
Primary citation	Chakrabortty, T.,Roy Chowdhury, S.,Ghosh, B.,Sen, U. Crystal Structure of VpsR Revealed Novel Dimeric Architecture and c-di-GMP Binding Site: Mechanistic Implications in Oligomerization, ATPase Activity and DNA Binding. J.Mol.Biol., 434:167354-167354, 2022 Cited by PubMed: 34774564 DOI: 10.1016/j.jmb.2021.167354 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4 Å)

Structure validation