7UXD

Crystal structure of APOBEC3G Catalytic domain complex with ssDNA containing 2'-deoxy Zebularine.

Summary for 7UXD

• Entry DOI: 10.2210/pdb7uxd/pdb
• Descriptor: DNA dC->dU-editing enzyme APOBEC-3G, DNA (5'-D(*AP*AP*TP*CP*CP*(DDN)P*AP*AP*A)-3'), ZINC ION, ... (4 entities in total)
• Functional Keywords: dna cytidine deaminase, apobec, apobec- inhibitor complex, zebularine, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 25881.35

Authors

Maiti, A.,Matsuo, H. (deposition date: 2022-05-05, release date: 2022-12-14, Last modification date: 2023-10-25)

• Primary citation: Maiti, A.,Hedger, A.K.,Myint, W.,Balachandran, V.,Watts, J.K.,Schiffer, C.A.,Matsuo, H.; Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state.; Nat Commun, 13:7117-7117, 2022; PubMed: 36402773; DOI: 10.1038/s41467-022-34752-1

Experimental method

X-RAY DIFFRACTION (1.5 Å)