7UVB

CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN S (LIGANDED SICKLE CELL HEMOGLOBIN) COMPLEXED WITH GBT021601

Summary for 7UVB

Entry DOI	10.2210/pdb7uvb/pdb
Descriptor	Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total)
Functional Keywords	metalloprotein, globulin, oxygen transport
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	65379.99
Authors	Partridge, J.R.,Kaya, E.,Xu, Q.,Li, Z.,Strutt, S.C.,Cathers, B.E. (deposition date: 2022-04-29, release date: 2023-04-05, Last modification date: 2023-10-25)
Primary citation	Dufu, K.,Alt, C.,Strutt, S.,Partridge, J.,Tang, T.,Siu, V.,Liao-Zou, H.,Rademacher, P.,Williams, A.T.,Muller, C.R.,Geng, X.,Pochron, M.P.,Dang, A.N.,Cabrales, P.,Li, Z.,Oksenberg, D.,Cathers, B.E. GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model. Br.J.Haematol., 202:173-183, 2023 Cited by PubMed: 36960712 DOI: 10.1111/bjh.18771 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation