7UT5

Acinetobacter baumannii dihydroorotate dehydrogenase bound with inhibitor DSM186

Summary for 7UT5

Entry DOI	10.2210/pdb7ut5/pdb
Descriptor	Dihydroorotate dehydrogenase (quinone), (4R)-7-methyl-N-[4-(pentafluoro-lambda~6~-sulfanyl)phenyl]imidazo[1,2-a]pyrimidin-5-amine, FLAVIN MONONUCLEOTIDE, ... (6 entities in total)
Functional Keywords	inhibitor, complex, flavoprotein, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological source	Acinetobacter baumannii
Total number of polymer chains	2
Total formula weight	78801.67
Authors	Deng, X.,Phillips, M.,Tomchick, D. (deposition date: 2022-04-26, release date: 2022-12-28, Last modification date: 2023-10-25)
Primary citation	Russo, T.A.,Umland, T.C.,Deng, X.,El Mazouni, F.,Kokkonda, S.,Olson, R.,Carlino-MacDonald, U.,Beanan, J.,Alvarado, C.L.,Tomchick, D.R.,Hutson, A.,Chen, H.,Posner, B.,Rathod, P.K.,Charman, S.A.,Phillips, M.A. Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii. Proc.Natl.Acad.Sci.USA, 119:e2213116119-e2213116119, 2022 Cited by PubMed: 36512492 DOI: 10.1073/pnas.2213116119 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation