7USZ
Human DDAH-1, holo (Zn-bound) form
Summary for 7USZ
Entry DOI | 10.2210/pdb7usz/pdb |
Descriptor | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, ZINC ION, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | cardiovascular enzyme, proton pump inhibitors, esomeprazole, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 63055.81 |
Authors | Smith, C.A.,Ghebre, Y.T. (deposition date: 2022-04-26, release date: 2022-05-11, Last modification date: 2023-10-18) |
Primary citation | Smith, C.A.,Ebrahimpour, A.,Novikova, L.,Farina, D.,Bailey, A.O.,Russell, W.K.,Jain, A.,Saltzman, A.B.,Malovannaya, A.,Prasad, B.V.V.,Hu, L.,Ghebre, Y.T. Esomeprazole covalently interacts with the cardiovascular enzyme dimethylarginine dimethylaminohydrolase: Insights into the cardiovascular risk of proton pump inhibitors. Biochim Biophys Acta Gen Subj, 1866:130149-130149, 2022 Cited by PubMed: 35472493DOI: 10.1016/j.bbagen.2022.130149 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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