7UK9

Integrin alaphIIBbeta3 complex with lamifiban (Mn)

Summary for 7UK9

Entry DOI	10.2210/pdb7uk9/pdb
Related	7L8P 7UDG 7UE0 7UFH 7UH8 7UJK
Descriptor	Integrin alpha-IIb heavy chain, MANGANESE (II) ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (14 entities in total)
Functional Keywords	complex, inhibitor, blood clotting, cell adhesion, cell adhesion-inhibitor complex, cell adhesion/inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	302747.99
Authors	Lin, F.-Y.,Zhu, J.,Zhu, J.,Springer, T.A. (deposition date: 2022-03-31, release date: 2022-08-17, Last modification date: 2023-10-25)
Primary citation	Lin, F.Y.,Li, J.,Xie, Y.,Zhu, J.,Huong Nguyen, T.T.,Zhang, Y.,Zhu, J.,Springer, T.A. A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell, 185:3533-3550.e27, 2022 Cited by PubMed: 36113427 DOI: 10.1016/j.cell.2022.08.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.60001966299 Å)

Structure validation