7UFC
Human CYP3A4 bound to an inhibitor
Summary for 7UFC
| Entry DOI | 10.2210/pdb7ufc/pdb |
| Descriptor | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, (2R)-3-phenyl-2-({(2S)-3-phenyl-2-[3-(pyridin-3-yl)propanamido]propyl}sulfanyl)-N-[2-(pyridin-3-yl)ethyl]propanamide, ... (4 entities in total) |
| Functional Keywords | cyp3a4, inhibitor, complex, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 56927.03 |
| Authors | Sevrioukova, I.F. (deposition date: 2022-03-22, release date: 2022-07-27, Last modification date: 2023-10-18) |
| Primary citation | Samuels, E.R.,Sevrioukova, I.F. Interaction of CYP3A4 with Rationally Designed Ritonavir Analogues: Impact of Steric Constraints Imposed on the Heme-Ligating Group and the End-Pyridine Attachment. Int J Mol Sci, 23:-, 2022 Cited by PubMed: 35806297DOI: 10.3390/ijms23137291 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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