7UAK

Structure of recombinantly assembled A53E alpha-synuclein fibrils

Summary for 7UAK

• Entry DOI: 10.2210/pdb7uak/pdb
• EMDB information: 26427
• Descriptor: Alpha-synuclein (1 entity in total)
• Functional Keywords: alpha-synuclein fibrils, a53e mutant, cryo-em structure, structural protein, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 87204.88

Authors

Zhou, K.,Zhou, H. (deposition date: 2022-03-13, release date: 2023-03-29, Last modification date: 2023-04-12)

• Primary citation: Sun, C.,Zhou, K.,DePaola IV, P.,Shin, W.S.,Hillyer, T.,Sawaya, M.R.,Zhu, R.,Peng, C.,Zhou, Z.H.,Jiang, L.; Cryo-EM structure of amyloid fibril formed by alpha-synuclein hereditary A53E mutation reveals a distinct protofilament interface.; J.Biol.Chem., 299:104566-104566, 2023; PubMed: 36871760; DOI: 10.1016/j.jbc.2023.104566

Experimental method

ELECTRON MICROSCOPY (3.38 Å)