7U9S
Crystal structure of human D-amino acid oxidase in complex with inhibitor
Summary for 7U9S
Entry DOI | 10.2210/pdb7u9s/pdb |
Descriptor | D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE, 5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1,4-dihydropyrazine-2,3-dione, ... (4 entities in total) |
Functional Keywords | fad, flavoprotein, oxidoreductase, peroxisome, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 81181.39 |
Authors | Skene, R.J.,Bell, J.A. (deposition date: 2022-03-11, release date: 2022-06-08, Last modification date: 2023-10-18) |
Primary citation | Tang, H.,Jensen, K.,Houang, E.,McRobb, F.M.,Bhat, S.,Svensson, M.,Bochevarov, A.,Day, T.,Dahlgren, M.K.,Bell, J.A.,Frye, L.,Skene, R.J.,Lewis, J.H.,Osborne, J.D.,Tierney, J.P.,Gordon, J.A.,Palomero, M.A.,Gallati, C.,Chapman, R.S.L.,Jones, D.R.,Hirst, K.L.,Sephton, M.,Chauhan, A.,Sharpe, A.,Tardia, P.,Dechaux, E.A.,Taylor, A.,Waddell, R.D.,Valentine, A.,Janssens, H.B.,Aziz, O.,Bloomfield, D.E.,Ladha, S.,Fraser, I.J.,Ellard, J.M. Discovery of a Novel Class of d-Amino Acid Oxidase Inhibitors Using the Schrodinger Computational Platform. J.Med.Chem., 65:6775-6802, 2022 Cited by PubMed: 35482677DOI: 10.1021/acs.jmedchem.2c00118 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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