7U3M
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with N-methylpiperazine Benzhydroxamic Acid
Summary for 7U3M
| Entry DOI | 10.2210/pdb7u3m/pdb |
| Descriptor | Polyamine deacetylase HDAC10, N-hydroxy-4-[(4-methylpiperazin-1-yl)methyl]benzamide, ZINC ION, ... (6 entities in total) |
| Functional Keywords | histone deacetylase, hydrolase |
| Biological source | Danio rerio (zebrafish) |
| Total number of polymer chains | 1 |
| Total formula weight | 75733.47 |
| Authors | Herbst-Gervasoni, C.J.,Christianson, D.W. (deposition date: 2022-02-27, release date: 2022-04-06, Last modification date: 2023-10-18) |
| Primary citation | Zeyen, P.,Zeyn, Y.,Herp, D.,Mahmoudi, F.,Yesiloglu, T.Z.,Erdmann, F.,Schmidt, M.,Robaa, D.,Romier, C.,Ridinger, J.,Herbst-Gervasoni, C.J.,Christianson, D.W.,Oehme, I.,Jung, M.,Kramer, O.H.,Sippl, W. Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells. Eur.J.Med.Chem., 234:114272-114272, 2022 Cited by PubMed: 35306288DOI: 10.1016/j.ejmech.2022.114272 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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