7U3L

GID4 in complex with compound 91

Summary for 7U3L

• Entry DOI: 10.2210/pdb7u3l/pdb
• Descriptor: Glucose-induced degradation protein 4 homolog, Nalpha-{(2R,4E)-2-[(N-benzylglycyl)amino]-5-phenylpent-4-enoyl}-N,4-dimethyl-L-phenylalaninamide, GLYCEROL, ... (4 entities in total)
• Functional Keywords: complex, inhibitor, protein degradation, peptide binding protein, peptide binding protein-inhibitor complex, peptide binding protein/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 20209.51

Authors

Chana, C.K.,Sicheri, F. (deposition date: 2022-02-27, release date: 2022-10-05, Last modification date: 2023-10-18)

• Primary citation: Chana, C.K.,Maisonneuve, P.,Posternak, G.,Grinberg, N.G.A.,Poirson, J.,Ona, S.M.,Ceccarelli, D.F.,Mader, P.,St-Cyr, D.J.,Pau, V.,Kurinov, I.,Tang, X.,Deng, D.,Cui, W.,Su, W.,Kuai, L.,Soll, R.,Tyers, M.,Rost, H.L.,Batey, R.A.,Taipale, M.,Gingras, A.C.,Sicheri, F.; Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.; J.Med.Chem., 65:12725-12746, 2022; PubMed: 36117290; DOI: 10.1021/acs.jmedchem.2c00509

Experimental method

X-RAY DIFFRACTION (2.295 Å)