7U3H

GID4 in complex with compound 7

Summary for 7U3H

Entry DOI	10.2210/pdb7u3h/pdb
Descriptor	Glucose-induced degradation protein 4 homolog, (5R)-N-(4-fluorophenyl)-5-methyl-4,5-dihydro-1,3-thiazol-2-amine (3 entities in total)
Functional Keywords	complex, inhibitor, protein degradation, peptide binding protein, peptide binding protein-inhibitor complex, peptide binding protein/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	19815.05
Authors	Chana, C.K.,Sicheri, F. (deposition date: 2022-02-27, release date: 2022-10-05, Last modification date: 2023-10-18)
Primary citation	Chana, C.K.,Maisonneuve, P.,Posternak, G.,Grinberg, N.G.A.,Poirson, J.,Ona, S.M.,Ceccarelli, D.F.,Mader, P.,St-Cyr, D.J.,Pau, V.,Kurinov, I.,Tang, X.,Deng, D.,Cui, W.,Su, W.,Kuai, L.,Soll, R.,Tyers, M.,Rost, H.L.,Batey, R.A.,Taipale, M.,Gingras, A.C.,Sicheri, F. Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4. J.Med.Chem., 65:12725-12746, 2022 Cited by PubMed: 36117290 DOI: 10.1021/acs.jmedchem.2c00509 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.798 Å)

Structure validation