7TTL

Stable-5-LOX elongated Ha2 (4 copies ASU)

Summary for 7TTL

Entry DOI	10.2210/pdb7ttl/pdb
Descriptor	Arachidonate 5-lipoxygenase, FE (II) ION (3 entities in total)
Functional Keywords	lipoxygenase, dioxygenase, membrane-binding, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	317968.35
Authors	Gilbert, N.C.,Newcomer, M.E. (deposition date: 2022-02-01, release date: 2022-08-31, Last modification date: 2023-10-18)
Primary citation	Gallegos, E.M.,Reed, T.D.,Mathes, F.A.,Guevara, N.V.,Neau, D.B.,Huang, W.,Newcomer, M.E.,Gilbert, N.C. Helical remodeling augments 5-lipoxygenase activity in the synthesis of proinflammatory mediators. J.Biol.Chem., 298:102282-102282, 2022 Cited by PubMed: 35863431 DOI: 10.1016/j.jbc.2022.102282 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.43 Å)

Structure validation