7THS

Macrocyclic plasmin inhibitor

Summary for 7THS

Entry DOI	10.2210/pdb7ths/pdb
Descriptor	Plasminogen, (6S,9R,20R,23S)-N-{[4-(aminomethyl)phenyl]methyl}-20-[(benzenesulfonyl)amino]-3,13,21-trioxo-2,6,9,14,22-pentaazatetracyclo[23.2.2.2~6,9~.2~15,18~]tritriaconta-1(27),15,17,25,28,30-hexaene-23-carboxamide, SULFATE ION, ... (5 entities in total)
Functional Keywords	protease, inhibitor, blood clotting, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	57019.34
Authors	Guojie, W. (deposition date: 2022-01-12, release date: 2023-01-18, Last modification date: 2023-10-25)
Primary citation	Wiedemeyer, S.J.A.,Wu, G.,Pham, T.L.P.,Lang-Henkel, H.,Perez Urzua, B.,Whisstock, J.C.,Law, R.H.P.,Steinmetzer, T. Synthesis and Structural Characterization of Macrocyclic Plasmin Inhibitors. Chemmedchem, 18:e202200632-e202200632, 2023 Cited by PubMed: 36710259 DOI: 10.1002/cmdc.202200632 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation