7TH4

T. thermophilus methylenetetrahydrofolate reductase complex with 5-formyltetrahydrofolate

Summary for 7TH4

Entry DOI	10.2210/pdb7th4/pdb
Descriptor	Methylenetetrahydrofolate reductase, FLAVIN-ADENINE DINUCLEOTIDE, N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, ... (6 entities in total)
Functional Keywords	tim barrel, flavin, oxidoreductase, 5-formyltetrahydrofolate
Biological source	Thermus thermophilus HB8
Total number of polymer chains	2
Total formula weight	68785.15
Authors	Yamada, K.,Koutmos, M. (deposition date: 2022-01-10, release date: 2023-01-18, Last modification date: 2023-10-25)
Primary citation	Yamada, K.,Mendoza, J.,Koutmos, M. 5-Formyltetrahydrofolate promotes conformational remodeling in a methylenetetrahydrofolate reductase active site and inhibits its activity. J.Biol.Chem., 299:102855-102855, 2022 Cited by PubMed: 36592927 DOI: 10.1016/j.jbc.2022.102855 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation