7TDW

Structure of FOXP3-DNA complex

Summary for 7TDW

• Entry DOI: 10.2210/pdb7tdw/pdb
• Descriptor: Forkhead box P3, DNA (5'-D(*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*AP*CP*TP*C)-3'), DNA (5'-D(P*GP*AP*GP*TP*AP*AP*AP*CP*AP*AP*AP*TP*TP*T)-3') (3 entities in total)
• Functional Keywords: foxp3, dimer, forkhead, dna, treg, transcription-dna complex, transcription/dna
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 3
• Total formula weight: 30715.01

Authors

Leng, F.,Hur, S. (deposition date: 2022-01-03, release date: 2022-08-10, Last modification date: 2023-10-18)

• Primary citation: Leng, F.,Zhang, W.,Ramirez, R.N.,Leon, J.,Zhong, Y.,Hou, L.,Yuki, K.,van der Veeken, J.,Rudensky, A.Y.,Benoist, C.,Hur, S.; The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis.; Immunity, 55:1354-, 2022; PubMed: 35926508; DOI: 10.1016/j.immuni.2022.07.002

Experimental method

X-RAY DIFFRACTION (4 Å)