7TCZ

Human cytomegalovirus protease mutant (C84A, C87A, C138A, C202A) in complex with inhibitor

Summary for 7TCZ

Entry DOI	10.2210/pdb7tcz/pdb
Descriptor	Assemblin, [1-(2-oxopropyl)-4-phenyl-1H-1,2,3-triazol-5-yl]methyl benzylcarbamate (3 entities in total)
Functional Keywords	protease, viral protein, hyrdrolase-hydrolase inhibitor complex, hyrdrolase/hydrolase inhibitor
Biological source	Human betaherpesvirus 5
Total number of polymer chains	1
Total formula weight	29325.81
Authors	Hulce, K.R.,Bohn, M.,Ongpipattanakul, C.,Jaishankar, P.,Renslo, A.R.,Craik, C.S. (deposition date: 2021-12-29, release date: 2022-01-12, Last modification date: 2023-10-18)
Primary citation	Hulce, K.R.,Jaishankar, P.,Lee, G.M.,Bohn, M.F.,Connelly, E.J.,Wucherer, K.,Ongpipattanakul, C.,Volk, R.F.,Chuo, S.W.,Arkin, M.R.,Renslo, A.R.,Craik, C.S. Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine. Cell Chem Biol, 29:785-798.e19, 2022 Cited by PubMed: 35364007 DOI: 10.1016/j.chembiol.2022.03.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.67 Å)

Structure validation