7TBT
Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 13/14
Summary for 7TBT
| Entry DOI | 10.2210/pdb7tbt/pdb |
| Descriptor | 3C-like proteinase, Nonstructural protein 13/14 (3 entities in total) |
| Functional Keywords | coronavirus, covid-19, covid, protease, drug resistance, complex, hydrolase, durg discovery, main protease, mpro, substrate complex, nsp 13/14, viral protein |
| Biological source | Severe acute respiratory syndrome coronavirus 2 More |
| Total number of polymer chains | 2 |
| Total formula weight | 34851.62 |
| Authors | Shaqra, A.M.,Schiffer, C.A. (deposition date: 2021-12-22, release date: 2022-06-22, Last modification date: 2023-10-18) |
| Primary citation | Shaqra, A.M.,Zvornicanin, S.N.,Huang, Q.Y.J.,Lockbaum, G.J.,Knapp, M.,Tandeske, L.,Bakan, D.T.,Flynn, J.,Bolon, D.N.A.,Moquin, S.,Dovala, D.,Kurt Yilmaz, N.,Schiffer, C.A. Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance. Nat Commun, 13:3556-3556, 2022 Cited by PubMed: 35729165DOI: 10.1038/s41467-022-31210-w PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
Download full validation report
