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7T9Y

Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 8/9

Summary for 7T9Y
Entry DOI10.2210/pdb7t9y/pdb
Descriptor3C-like proteinase, Nonstructural protein 8/9, GLYCEROL, ... (4 entities in total)
Functional Keywordscoronavirus, covid-19, covid, protease, drug resistance, complex, hydrolase, durg discovery, main protease, mpro, substrate complex, nsp 8/9, viral protein
Biological sourceSevere acute respiratory syndrome coronavirus 2
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Total number of polymer chains4
Total formula weight70003.64
Authors
Shaqra, A.M.,Schiffer, C.A. (deposition date: 2021-12-20, release date: 2022-06-22, Last modification date: 2023-10-18)
Primary citationShaqra, A.M.,Zvornicanin, S.N.,Huang, Q.Y.J.,Lockbaum, G.J.,Knapp, M.,Tandeske, L.,Bakan, D.T.,Flynn, J.,Bolon, D.N.A.,Moquin, S.,Dovala, D.,Kurt Yilmaz, N.,Schiffer, C.A.
Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.
Nat Commun, 13:3556-3556, 2022
Cited by
PubMed: 35729165
DOI: 10.1038/s41467-022-31210-w
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.18 Å)
Structure validation

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