7T3V

Metal dependent activation of Plasmodium falciparum M17 aminopeptidase, spacegroup P22121 after crystals soaked with Zn2+

Summary for 7T3V

Entry DOI	10.2210/pdb7t3v/pdb
Descriptor	M17 leucyl aminopeptidase, CARBONATE ION, ZINC ION, ... (6 entities in total)
Functional Keywords	metallo aminopeptidase, malaria, peptide binding protein, hydrolase
Biological source	Plasmodium falciparum (malaria parasite P. falciparum)
Total number of polymer chains	6
Total formula weight	353040.10
Authors	Webb, C.T.,McGowan, S. (deposition date: 2021-12-08, release date: 2022-06-29, Last modification date: 2023-10-18)
Primary citation	Webb, C.T.,Yang, W.,Riley, B.T.,Hayes, B.K.,Sivaraman, K.K.,Malcolm, T.R.,Harrop, S.,Atkinson, S.C.,Kass, I.,Buckle, A.M.,Drinkwater, N.,McGowan, S. A metal ion-dependent conformational switch modulates activity of the Plasmodium M17 aminopeptidase. J.Biol.Chem., 298:102119-102119, 2022 Cited by PubMed: 35691342 DOI: 10.1016/j.jbc.2022.102119 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation