7T1I

Crystal structure of CAB1 Pantothenate Kinase from Saccharomyces cerevisiae in complex with compound YU385597

Summary for 7T1I

• Entry DOI: 10.2210/pdb7t1i/pdb
• Related: 6UJ5 7T1G 7T1H
• Descriptor: Pantothenate kinase CAB1, (8S)-2-{[(4-tert-butylphenyl)methyl]amino}-5-[(piperidin-1-yl)methyl][1,2,4]triazolo[1,5-a]pyrimidin-7(6H)-one, SULFATE ION, ... (6 entities in total)
• Functional Keywords: kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Saccharomyces cerevisiae S288C
• Total number of polymer chains: 2
• Total formula weight: 85520.10

Authors

Gihaz, S.,Ben Mamoun, C. (deposition date: 2021-12-02, release date: 2022-10-05, Last modification date: 2023-10-18)

• Primary citation: Gihaz, S.,Gareiss, P.,Choi, J.Y.,Renard, I.,Pal, A.C.,Surovsteva, Y.,Chiu, J.E.,Thekkiniath, J.,Plummer, M.,Hungerford, W.,Montgomery, M.L.,Hosford, A.,Adams, E.M.,Lightfoot, J.D.,Fox 3rd, D.,Ojo, K.K.,Staker, B.L.,Fuller, K.,Ben Mamoun, C.; High-resolution crystal structure and chemical screening reveal pantothenate kinase as a new target for antifungal development.; Structure, 30:1494-, 2022; PubMed: 36167065; DOI: 10.1016/j.str.2022.09.001

Experimental method

X-RAY DIFFRACTION (2.4 Å)