7T1D

Human SIRT2 in complex with small molecule 359

Summary for 7T1D

Entry DOI	10.2210/pdb7t1d/pdb
Descriptor	NAD-dependent protein deacetylase sirtuin-2, ZINC ION, SULFATE ION, ... (7 entities in total)
Functional Keywords	allosteric inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	70219.69
Authors	Kulp, J.L.,Remiszewski, S.,Todd, M.,Chiang, L.W. (deposition date: 2021-12-01, release date: 2023-05-17, Last modification date: 2024-04-03)
Primary citation	Roche, K.L.,Remiszewski, S.,Todd, M.J.,Kulp 3rd, J.L.,Tang, L.,Welsh, A.V.,Barry, A.P.,De, C.,Reiley, W.W.,Wahl, A.,Garcia, J.V.,Luftig, M.A.,Shenk, T.,Tonra, J.R.,Murphy, E.A.,Chiang, L.W. An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity. J.Clin.Invest., 133:-, 2023 Cited by PubMed: 37317966 DOI: 10.1172/JCI158978 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation