7SZK

Cryo-EM structure of 27a bound to E. coli RNAP and rrnBP1 promoter complex

Summary for 7SZK

• Entry DOI: 10.2210/pdb7szk/pdb
• EMDB information: 25570 25571
• Descriptor: DNA-directed RNA polymerase subunit alpha, ZINC ION, DNA-directed RNA polymerase subunit beta, ... (10 entities in total)
• Functional Keywords: transcription, antibiotics, rifamycin, transferase-dna-antibiotic complex, transferase/dna/antibiotic
• Biological source: Escherichia coli K-12; More
• Total number of polymer chains: 8
• Total formula weight: 500650.54

Authors

Shin, Y.,Murakami, K.S. (deposition date: 2021-11-28, release date: 2022-07-13, Last modification date: 2024-02-28)

• Primary citation: Rajeswaran, W.,Ashkar, S.R.,Lee, P.H.,Yeomans, L.,Shin, Y.,Franzblau, S.G.,Murakami, K.S.,Showalter, H.D.,Garcia, G.A.; Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis.; Acs Infect Dis., 8:1422-1438, 2022; PubMed: 35772744; DOI: 10.1021/acsinfecdis.1c00636

Experimental method

ELECTRON MICROSCOPY (2.94 Å)