7SZ1
Cryo-EM structure of the extracellular module of the full-length EGFR L834R bound to EGF. "tips-separated" conformation
Summary for 7SZ1
| Entry DOI | 10.2210/pdb7sz1/pdb |
| Related | 7SZ0 |
| EMDB information | 25558 25559 |
| Descriptor | Epidermal growth factor receptor, Epidermal growth factor (2 entities in total) |
| Functional Keywords | receptor tyrosine kinases, epidermal growth factor receptor, signaling protein, signaling protein-receptor complex, signaling protein/receptor |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 281412.80 |
| Authors | Huang, Y.,Ognjenovic, J.,Karandur, D.,Miller, K.,Merk, A.,Subramaniam, S.,Kuriyan, J. (deposition date: 2021-11-25, release date: 2021-12-22) |
| Primary citation | Huang, Y.,Ognjenovic, J.,Karandur, D.,Miller, K.,Merk, A.,Subramaniam, S.,Kuriyan, J. A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10:-, 2021 Cited by PubMed: 34846302DOI: 10.7554/eLife.73218 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
Download full validation report
