7SUY

Carbonic Anhydrase IX-mimic Complexed with 2-((3-Aminopropyl)(phenethyl)amino)-N-(4-fluorobenzyl)-N-(4-sulfamoylphenethyl)acetamide

Summary for 7SUY

• Entry DOI: 10.2210/pdb7suy/pdb
• Descriptor: Carbonic anhydrase 2, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, N-[(furan-2-yl)methyl]-N-[2-(4-sulfamoylphenyl)ethyl]glycinamide, ... (5 entities in total)
• Functional Keywords: inhibitor, carbonic anhydrase, metal binding protein, lyase-inhibitor complex, lyase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 29369.41

Authors

Combs, J.E.,McKenna, R. (deposition date: 2021-11-18, release date: 2022-04-06, Last modification date: 2023-10-18)

• Primary citation: Bonardi, A.,Bua, S.,Combs, J.,Lomelino, C.,Andring, J.,Osman, S.M.,Toti, A.,Di Cesare Mannelli, L.,Gratteri, P.,Ghelardini, C.,McKenna, R.,Nocentini, A.,Supuran, C.T.; The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII.; J Enzyme Inhib Med Chem, 37:930-939, 2022; PubMed: 35306936; DOI: 10.1080/14756366.2022.2053526

Experimental method

X-RAY DIFFRACTION (1.405 Å)