7SS7
Crystal structure of Klebsiella LpxH in complex with JH-LPH-50
Summary for 7SS7
| Entry DOI | 10.2210/pdb7ss7/pdb |
| Descriptor | UDP-2,3-diacylglucosamine hydrolase, MANGANESE (II) ION, 6-{[(4-{4-[3-chloro-5-(trifluoromethyl)phenyl]piperazine-1-sulfonyl}phenyl)carbamoyl]amino}-N-hydroxyhexanamide, ... (5 entities in total) |
| Functional Keywords | lpxh, lipid a, lps, antibiotic, gram-negative bacteria, hydrolase-antibiotic complex, hydrolase/antibiotic |
| Biological source | Klebsiella pneumoniae |
| Total number of polymer chains | 1 |
| Total formula weight | 30701.99 |
| Authors | Cho, J.,Cochrane, C.S.,Zhou, P. (deposition date: 2021-11-09, release date: 2023-04-12, Last modification date: 2023-10-25) |
| Primary citation | Kwak, S.H.,Skyler Cochrane, C.,Cho, J.,Dome, P.A.,Ennis, A.F.,Kim, J.H.,Zhou, P.,Hong, J. Development of LpxH Inhibitors Chelating the Active Site Dimanganese Metal Cluster of LpxH. Chemmedchem, 18:e202300023-e202300023, 2023 Cited by PubMed: 37014664DOI: 10.1002/cmdc.202300023 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.73 Å) |
Structure validation
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