7SS6

Structure of Klebsiella LpxH in complex with JH-LPH-45

Summary for 7SS6

Entry DOI	10.2210/pdb7ss6/pdb
Descriptor	UDP-2,3-diacylglucosamine hydrolase, MANGANESE (II) ION, 5-{4-[3-chloro-5-(trifluoromethyl)phenyl]piperazine-1-sulfonyl}-N-[5-(hydroxyamino)-5-oxopentyl]-2,3-dihydro-1H-indole-1-carboxamide, ... (5 entities in total)
Functional Keywords	lpxh, lipid a, antibiotic, gram-negative bacteria, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	30589.87
Authors	Cho, J.,Cochrane, C.S.,Zhou, P. (deposition date: 2021-11-09, release date: 2023-04-12, Last modification date: 2023-10-25)
Primary citation	Kwak, S.H.,Skyler Cochrane, C.,Cho, J.,Dome, P.A.,Ennis, A.F.,Kim, J.H.,Zhou, P.,Hong, J. Development of LpxH Inhibitors Chelating the Active Site Dimanganese Metal Cluster of LpxH. Chemmedchem, 18:e202300023-e202300023, 2023 Cited by PubMed: 37014664 DOI: 10.1002/cmdc.202300023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation