7SQO
Structure of the orexin-2 receptor(OX2R) bound to TAK-925, Gi and scFv16
Summary for 7SQO
Entry DOI | 10.2210/pdb7sqo/pdb |
EMDB information | 25389 |
Descriptor | Orexin receptor type 2, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total) |
Functional Keywords | class a gpcr, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 165739.63 |
Authors | McGrath, A.P.,Kang, Y.,Flinspach, M. (deposition date: 2021-11-05, release date: 2022-05-25, Last modification date: 2022-07-06) |
Primary citation | Yin, J.,Kang, Y.,McGrath, A.P.,Chapman, K.,Sjodt, M.,Kimura, E.,Okabe, A.,Koike, T.,Miyanohana, Y.,Shimizu, Y.,Rallabandi, R.,Lian, P.,Bai, X.,Flinspach, M.,De Brabander, J.K.,Rosenbaum, D.M. Molecular mechanism of the wake-promoting agent TAK-925. Nat Commun, 13:2902-2902, 2022 Cited by PubMed: 35614071DOI: 10.1038/s41467-022-30601-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.17 Å) |
Structure validation
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