7SMV

Crystallization of feline coronavirus Mpro with GC376 reveals mechanism of inhibition

Summary for 7SMV

• Entry DOI: 10.2210/pdb7smv/pdb
• Descriptor: 3C-like proteinase, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide (3 entities in total)
• Functional Keywords: viral protein, hydrolase-hydrolase inhibitor complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Feline coronavirus
• Total number of polymer chains: 2
• Total formula weight: 67094.05

Authors

Khan, M.B.,Lu, J.,Young, H.S.,Lemieux, M.J. (deposition date: 2021-10-26, release date: 2022-04-06, Last modification date: 2023-10-18)

• Primary citation: Lu, J.,Chen, S.A.,Khan, M.B.,Brassard, R.,Arutyunova, E.,Lamer, T.,Vuong, W.,Fischer, C.,Young, H.S.,Vederas, J.C.,Lemieux, M.J.; Crystallization of Feline Coronavirus M pro With GC376 Reveals Mechanism of Inhibition.; Front Chem, 10:852210-852210, 2022; PubMed: 35281564; DOI: 10.3389/fchem.2022.852210

Experimental method

X-RAY DIFFRACTION (1.93 Å)