7SGG

Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with SAHA

Summary for 7SGG

Entry DOI	10.2210/pdb7sgg/pdb
Descriptor	Polyamine deacetylase HDAC10, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, DI(HYDROXYETHYL)ETHER, ... (8 entities in total)
Functional Keywords	histone deacetylase, hydrolase
Biological source	Danio rerio (Zebrafish)
Total number of polymer chains	1
Total formula weight	75972.56
Authors	Herbst-Gervasoni, C.J.,Christianson, D.W. (deposition date: 2021-10-05, release date: 2022-10-05, Last modification date: 2023-10-18)
Primary citation	Steimbach, R.R.,Herbst-Gervasoni, C.J.,Lechner, S.,Stewart, T.M.,Klinke, G.,Ridinger, J.,Geraldy, M.N.E.,Tihanyi, G.,Foley, J.R.,Uhrig, U.,Kuster, B.,Poschet, G.,Casero Jr., R.A.,Medard, G.,Oehme, I.,Christianson, D.W.,Gunkel, N.,Miller, A.K. Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J.Am.Chem.Soc., 144:18861-18875, 2022 Cited by PubMed: 36200994 DOI: 10.1021/jacs.2c05030 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation