7SCK
Cryo-EM structure of the human Exostosin-1 and Exostosin-2 heterodimer in complex with a 7-sugar oligosaccharide acceptor analog
Summary for 7SCK
Entry DOI | 10.2210/pdb7sck/pdb |
EMDB information | 25037 |
Descriptor | Exostosin-1, Exostosin-2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | exostosin1, exostosin2, glycosyltransferase, heparan sulfate, acceptor, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 163089.71 |
Authors | |
Primary citation | Li, H.,Chapla, D.,Amos, R.A.,Ramiah, A.,Moremen, K.W.,Li, H. Structural basis for heparan sulfate co-polymerase action by the EXT1-2 complex. Nat.Chem.Biol., 19:565-574, 2023 Cited by PubMed: 36593275DOI: 10.1038/s41589-022-01220-2 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.8 Å) |
Structure validation
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