7SBN

Human glutaminase C (Y466W) with L-Gln, closed conformation

Summary for 7SBN

Entry DOI	10.2210/pdb7sbn/pdb
Descriptor	Isoform 3 of Glutaminase kidney isoform, mitochondrial, GLUTAMINE (3 entities in total)
Functional Keywords	cancer, mitochondrial metabolism, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	238507.09
Authors	Nguyen, T.-T.T.,Cerione, R.A. (deposition date: 2021-09-25, release date: 2022-02-02, Last modification date: 2023-10-18)
Primary citation	Nguyen, T.T.,Ramachandran, S.,Hill, M.J.,Cerione, R.A. High-resolution structures of mitochondrial glutaminase C tetramers indicate conformational changes upon phosphate binding. J.Biol.Chem., 298:101564-101564, 2022 Cited by PubMed: 34999118 DOI: 10.1016/j.jbc.2022.101564 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.14 Å)

Structure validation