7S76

HBV CAPSID Y132A WITH COMPOUND 10b AT 2.5A RESOLUTION

Summary for 7S76

• Entry DOI: 10.2210/pdb7s76/pdb
• Descriptor: Capsid protein, (1-methyl-1H-1,2,4-triazol-3-yl)methyl {(4S)-1-[(3-chloro-4-fluorophenyl)carbamoyl]-2-methyl-2,4,5,6-tetrahydrocyclopenta[c]pyrrol-4-yl}carbamate (2 entities in total)
• Functional Keywords: core, viral protein, inhibitor, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Hepatitis B virus genotype A (HBV)
• Total number of polymer chains: 6
• Total formula weight: 110708.65

Authors

Olland, A.M.,Suto, R.K. (deposition date: 2021-09-15, release date: 2022-05-04, Last modification date: 2023-10-18)

• Primary citation: Cole, A.G.,Kultgen, S.G.,Mani, N.,Ardzinski, A.,Fan, K.Y.,Thi, E.P.,Dorsey, B.D.,Stever, K.,Chiu, T.,Tang, S.,Daly, O.,Phelps, J.R.,Harasym, T.,Olland, A.,Suto, R.K.,Sofia, M.J.; The identification of highly efficacious functionalised tetrahydrocyclopenta[ c ]pyrroles as inhibitors of HBV viral replication through modulation of HBV capsid assembly.; Rsc Med Chem, 13:343-349, 2022; PubMed: 35434625; DOI: 10.1039/d1md00318f

Experimental method

X-RAY DIFFRACTION (2.5 Å)