7S59

Crystal structure of the tick evasin EVA-P974 complexed to a chimera made of human chemokines CCL7 and CCL8

Summary for 7S59

Entry DOI	10.2210/pdb7s59/pdb
Descriptor	Evasin P974, chimera protein of C-C motif chemokine 7 and C-C motif chemokine 8,C-C motif chemokine 7, SULFATE ION, ... (4 entities in total)
Functional Keywords	inflammation, evasin, chemokine binder, evasin-chemokine complex, immune system
Biological source	Amblyomma cajennense (Cayenne tick, Acarus cajennensis) More
Total number of polymer chains	4
Total formula weight	37409.14
Authors	Bhusal, R.P.,Devkota, S.R.,Aryal, P.,Wilce, M.C.J.,Stone, M.J. (deposition date: 2021-09-10, release date: 2022-03-16, Last modification date: 2023-10-18)
Primary citation	Bhusal, R.P.,Aryal, P.,Devkota, S.R.,Pokhrel, R.,Gunzburg, M.J.,Foster, S.R.,Lim, H.D.,Payne, R.J.,Wilce, M.C.J.,Stone, M.J. Structure-guided engineering of tick evasins for targeting chemokines in inflammatory diseases. Proc.Natl.Acad.Sci.USA, 119:-, 2022 Cited by PubMed: 35217625 DOI: 10.1073/pnas.2122105119 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.39 Å)

Structure validation