7S1Y

Cryo-EM structure of human NKCC1 K289NA492E bound with bumetanide

Summary for 7S1Y

• Entry DOI: 10.2210/pdb7s1y/pdb
• EMDB information: 24807 24812 24813
• Descriptor: Solute carrier family 12 member 2, POTASSIUM ION, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: ion transport, transport protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 264561.12

Authors

Zhao, Y.X.,Cao, E.h. (deposition date: 2021-09-02, release date: 2022-05-25)

• Primary citation: Zhao, Y.,Roy, K.,Vidossich, P.,Cancedda, L.,De Vivo, M.,Forbush, B.,Cao, E.; Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide; Nat Commun, 13:2747-, 2022; DOI: 10.1038/s41467-022-30407-3

Experimental method

ELECTRON MICROSCOPY (3.6 Å)