7RYX

S. CEREVISIAE CYP51 COMPLEXED WITH VT-1129

Summary for 7RYX

• Entry DOI: 10.2210/pdb7ryx/pdb
• Related: 5UL0
• Descriptor: Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, (2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-{5-[4-(trifluoromethoxy)phenyl]pyridin-2-yl}propan-2-ol, ... (4 entities in total)
• Functional Keywords: vt-1129, cyp51, oxidoreductase-oxidoreductase inhibitor complex, sterol biosynthesis, oxidoreductase, oxidoreductase/oxidoreductase inhibitor
• Biological source: Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
• Total number of polymer chains: 1
• Total formula weight: 62600.62

Authors

Ruma, Y.N.,Sagatova, A.,Keniya, M.V.,Tyndall, J.D.,Monk, B.C. (deposition date: 2021-08-26, release date: 2021-09-08, Last modification date: 2023-10-18)

• Primary citation: Ruma, Y.N.,Keniya, M.V.,Tyndall, J.D.A.,Monk, B.C.; Characterisation of Candida parapsilosis CYP51 as a Drug Target Using Saccharomyces cerevisiae as Host.; J Fungi, 8:-, 2022; PubMed: 35050009; DOI: 10.3390/jof8010069

Experimental method

X-RAY DIFFRACTION (2.1 Å)