7RYA

S. CEREVISIAE CYP51 I471T MUTANT COMPLEXED WITH ITRACONAZOLE

Summary for 7RYA

Entry DOI	10.2210/pdb7rya/pdb
Related	4ZDY 4ZE2 5EQB 5ESG 5ESH 5ESK 5ESL
Descriptor	Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, ... (4 entities in total)
Functional Keywords	cyp51, oxidoreductase-oxidoreductase inhibitor complex, sterol biosynthesis, oxidoreductase, oxidoreductase/oxidoreductase inhibitor
Biological source	Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Total number of polymer chains	1
Total formula weight	63195.28
Authors	Graham, D.O.,Wilson, R.K.,Ruma, Y.N.,Keniya, M.V.,Tyndall, J.D.,Monk, B.C. (deposition date: 2021-08-24, release date: 2021-09-01, Last modification date: 2023-10-18)
Primary citation	Graham, D.O.,Wilson, R.K.,Ruma, Y.N.,Keniya, M.V.,Tyndall, J.D.A.,Monk, B.C. Structural Insights into the Azole Resistance of the Candida albicans Darlington Strain Using Saccharomyces cerevisiae Lanosterol 14 alpha-Demethylase as a Surrogate. J Fungi (Basel), 7:-, 2021 Cited by PubMed: 34829185 DOI: 10.3390/jof7110897 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation