7RY1

human Hsp90_MC domain structure

Summary for 7RY1

Entry DOI	10.2210/pdb7ry1/pdb
Descriptor	Heat shock protein HSP 90-alpha, N-[2-(1-MALEIMIDYL)ETHYL]-7-DIETHYLAMINOCOUMARIN-3-CARBOXAMIDE (2 entities in total)
Functional Keywords	hsp90, chaperone, hexamer
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	150186.54
Authors	Peng, S.,Deng, J.,Matts, R. (deposition date: 2021-08-24, release date: 2022-05-11, Last modification date: 2023-10-18)
Primary citation	Peng, S.,Woodruff, J.,Pathak, P.K.,Matts, R.L.,Deng, J. Crystal structure of the middle and C-terminal domains of Hsp90 alpha labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target. Acta Crystallogr D Struct Biol, 78:571-585, 2022 Cited by PubMed: 35503206 DOI: 10.1107/S2059798322002261 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.523 Å)

Structure validation