7RSP

Structure of the VPS34 kinase domain with compound 14

Summary for 7RSP

• Entry DOI: 10.2210/pdb7rsp/pdb
• Descriptor: Phosphatidylinositol 3-kinase catalytic subunit type 3, GLYCEROL, (7R,8R)-2-[(3R)-3-methylmorpholin-4-yl]-7-(propan-2-yl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one, ... (4 entities in total)
• Functional Keywords: vps34 inhibitor, endosomal trafficking, authophagy, oncoprotein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 140984.84

Authors

Hu, D.X.,Patel, S.,Chen, H.,Wang, S.,Staben, S.,Dimitrova, Y.N.,Wallweber, H.A.,Lee, J.Y.,Chan, G.K.Y.,Sneeringer, C.J.,Prangley, M.S.,Moffat, J.G.,Wu, C.,Schutt, L.K.,Salphati, L.,Pang, J.,McNamara, E.,Huang, H.,Chen, Y.,Wang, Y.,Zhao, W.,Lim, J.,Murthy, A.,Siu, M. (deposition date: 2021-08-11, release date: 2021-11-24, Last modification date: 2024-04-03)

• Primary citation: Hu, D.X.,Patel, S.,Chen, H.,Wang, S.,Staben, S.T.,Dimitrova, Y.N.,Wallweber, H.A.,Lee, J.Y.,Chan, G.K.Y.,Sneeringer, C.J.,Prangley, M.S.,Moffat, J.G.,Wu, K.C.,Schutt, L.K.,Salphati, L.,Pang, J.,McNamara, E.,Huang, H.,Chen, Y.,Wang, Y.,Zhao, W.,Lim, J.,Murthy, A.,Siu, M.; Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors.; J.Med.Chem., 65:11500-11512, 2022; PubMed: 34779204; DOI: 10.1021/acs.jmedchem.1c01180

Experimental method

X-RAY DIFFRACTION (1.67 Å)