7RRF

Carbonic Anhydrase IX-mimic in complex with Beta-Galactose_2C

Summary for 7RRF

• Entry DOI: 10.2210/pdb7rrf/pdb
• Descriptor: Carbonic anhydrase 2, 2-[1-(1,1,3-trioxo-2,3-dihydro-1H-1lambda~6~,2-benzothiazol-6-yl)-1H-1,2,3-triazol-4-yl]ethyl beta-L-gulopyranoside, ZINC ION, ... (4 entities in total)
• Functional Keywords: cancer, galactose, inhibitor, metal binding protein, ligase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 29888.14

Authors

Combs, J.E.,McKenna, R. (deposition date: 2021-08-09, release date: 2022-08-24, Last modification date: 2023-10-18)

• Primary citation: Combs, J.E.,Murray, A.B.,Lomelino, C.L.,Mboge, M.Y.,Frost, S.C.,Horenstein, N.A.,McKenna, R.,Becker, H.M.; Inhibition of Carbonic Anhydrase IX and Monocarboxylate Transporters 1 and 4 in breast cancer via novel inhibition with Beta-Galactose 2C; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.45 Å)